Moreover, a mechanistic study has revealed that FZHY can decrease the expression levels of α-SMA, CTGF, TIMP-1, TGF-β1, and Smads, thereby reducing hepatic apoptosis, acute liver injury, and liver fibrosis (Cheng et al., 2013; Xie et al., 2013). Here, TIMP1 is linked to Hepatic fibrosis.