Moreover, a mechanistic study has revealed that FZHY can decrease the expression levels of α-SMA, CTGF, TIMP-1, TGF-β1, and Smads, thereby reducing hepatic apoptosis, acute liver injury, and liver fibrosis (Cheng et al., 2013; Xie et al., 2013). The gene discussed is TGFB1; the disease is Hepatic fibrosis.