Hence, to gain deep insights on the effect of our drugs on induction of apoptosis, following their efficacy on oxidative stress and proliferation, we analysed the gene and protein expression of the mediators of the intrinsic pathway of apoptosis namely, BAX, BAD, caspase −9, 8 and the executioner caspase-3 in the tumor tissues of the treated rats. This evidence concerns the gene CASP3 and neoplasm.