FOXO3 and cancer: Further, individually “M” has been proven to bring about 5′adenosine monophosphate-activated protein kinase (AMPK) mediated inhibition of fork-head box O3 (FOXO3) and AKT in various cancers (Sato et al., 2012; Chou et al., 2014; Nozhat et al., 2018; Mazurek et al., 2020a).