Similarly, studies have reported “M” to enhance radiodensity in non-small lung cancer cells (Sun et al., 2022) and supressed chemoresistance in human hepatocellular carcinoma (HepG2) cells (Cai et al., 2020) by destabilizing Nrf2 One interesting observation from our study was that the triple-drug combination upregulated the levels of ROS, which was indirectly proportional to the levels of Nrf2 and HIF-1α, that could impede the survival of glioma tumor. Here, HIF1A is linked to hepatocellular carcinoma.