PPARδ, another isotype, is highly expressed in tissues such as the lung, kidney, and heart, and can regulate the expression of target genes involved in cardiovascular diseases, cancers, and gastrointestinal diseases in combination with progression and treatment at the DNA-binding domain (Ratziu et al., 2016; Kadayat et al., 2020; Xiao and Wang, 2022). The gene discussed is PPARD; the disease is cancer.