SETD2 and nervous system disorder: Dysregulation of SETD2 function has also been reported in a series of neurological disorders and cancers including ID/DD (Faundes et al., 2018), autism/ASD (D'Gama et al., 2015), renal clear cell carcinoma (Rao et al., 2021) and acute lymphocytic leukemia (Mar et al., 2014).