Overall, the data summarized here suggest that PTX3 could play a role both in thyroid cancer, as demonstrated by the presence of PTX3 among the gene signatures associated to the different subtypes of thyroid carcinomas, and in the nodular remodeling of the thyroid, as suggested by PTX3 overexpression from goiter patients and GD patients. This evidence concerns the gene PTX3 and thyroid gland carcinoma.