A recent study identified a four genes signature including PTX3, 3′-phosphoadenosine 5′-phosphosulfate synthase 2 (PAPSS2), procollagen C-endopeptidase enhancer 2 (PCOLCE2) and transforming growth factor beta receptor 3 (TGFBR3) for papillary carcinoma as marker for risk stratification and survival prediction (54). Here, PTX3 is linked to thyroid gland papillary carcinoma.