Also, it was confirmed that the human ether-à-go-go-related gene (hERG) and cardiac L-type calcium channel (Cav1.2), which contribute to ventricular repolarization and are the leading causes of drug-induced cardiac arrhythmia in drug development, were also expressing in the cell membrane (Figure 3A). The gene discussed is CACNA1C; the disease is chronic obstructive pulmonary disease.