Interestingly, loss of Cav1.3 function in humans was associated with sinoatrial node dysfunction and deafness (SANDD) syndrome with a cardiac and auditory phenotype similar to Cav1.3−/− mice (Baig et al., 2011; Liaqat et al., 2019; Torrente et al., 2020). This evidence concerns the gene CACNA1D and sinoatrial node dysfunction and deafness.