Particularly, cardiac Ca2+ (Cav1.2/Cav1.3) channel expression and ICaL, along with the action potential durations, were significantly reduced in mice with frameshift human natriuretic peptide precursor A genes, providing further evidence of the significant role of Cav1.3 in AF (Menon et al., 2019). Here, CACNA1C is linked to atrial fibrillation.