GDPD5 and neuroblastoma: Moreover, GDE2 has been implicated in oligodendrocyte maturation, neuroblastoma differentiation and motor neuron degeneration, indicating the broad necessity to regulate GPI-AP release in varied biological settings (Cave et al., 2017; Matas-Rico et al., 2017; Choi et al., 2020a; Nakamura et al., 2021).