APEX1 and neuroblastoma: Because MYCN encodes the Myc oncogenic transcription factor, we compared the G1 genes to those putative Myc target genes that can be up-regulated by Myc and whose promoters are bound by Myc (see Methods), we found only three genes (CKS2, APEX1, HSPD1) shared between these two gene sets, indicating that the genetic regulatory networks underlying the genesis of NB are much more complicated than those related to the Myc regulatory network.