CEP89 and neuroblastoma: We also noted 38 genes annotated in the significantly changed pathways, including upregulation of mitochondrial DNA encoding genes (MRPL50, MRPS23, MRPL42, MRPL32, MRPL47, MRPL3, MRPL21, and MRPS21) and downregulation of CEP89, AIFM2, and ZNFX1 in the NB cell lines (Figure 1D).