PCa derived miRNAs miR-100, miR-21, and miR-139, increases expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and metalloproteinases in cancer-associated fibroblasts, increasing their proliferation, differentiation, and migration (Sánchez et al., 2016). The gene discussed is TNFSF11; the disease is posterior cortical atrophy.