Even though ATF6α plays protective roles in pathological settings such as those induced by ischemia/reperfusion damage in several organs [(Blackwood et al., 2019), and reviewed in (18)], synergistic effects between ATF6α and ATF6β have also been reported in development (Yamamoto et al., 2007) and cardiac failure settings (Correll et al., 2019). Here, ATF6 is linked to heart failure.