HJURP and plasma cell myeloma: The study also revealed that transcriptional activation of the HJURP gene in t (4; 14) myeloma resulted from the presence of a super-enhancer (SE) distal to the HJURP gene promoter, and was induced by binding of NSD2/BRD4 complexes to those two regions (Jia et al., 2022) (Figure 4).