Specifically, it was reported that HJURP promotes HCC cell survival by regulating the nuclear-cytoplasmic translocation and ubiquitin-mediated degradation of p21 through the MAPK/ERK1/2 and AKT/GSK3β pathways, thus promoting G1/S phase transition (Chen et al., 2018). This evidence concerns the gene HJURP and hepatocellular carcinoma.