Mechanistically, HJURP regulates p21 ubiquitination through the GSK3β/JNK signaling pathway and promotes p21 ubiquitin-dependent proteasomal degradation; this in turn promotes G1/S phase transition, ultimately leading to PCa progression (Lai et al., 2021) (Figure 4). The gene discussed is CDKN1A; the disease is posterior cortical atrophy.