On the other hand, HJURP activates EMT through upregulation of Sphingosine kinase 1 (SPHK1), causing upregulation of vimentin and N-cadherin and downregulation of E-cadherin to promote tumor cell migration, invasion, and metastasis in vivo (Chen T. et al., 2019) (Figure 4). The gene discussed is SPHK1; the disease is neoplasm.