UBE2L6 and hyperinsulinism: A recent study demonstrated elevated expression of the ubiquitin/ISG15-conjugating enzyme UBE2L6 in white adipose tissue from obese mice and humans; moreover, HFD-fed mice with adipose tissue-specific Ube2l6 ablation had a reduced content of subcutaneous and visceral white adipose tissue, as well as attenuated glucose intolerance, insulin resistance, compensatory hyperinsulinemia, hypercholesterolemia, and hepatic steatosis (Wei et al., 2021).