The same study found that ISG15 expression in human peripheral blood mononuclear cells positively correlated with systolic and diastolic blood pressure and with carotid intima-media thickness and also found elevated ISG15 expression in human and mouse abdominal aortic aneurysms (Gonzalez-Amor et al., 2022). The gene discussed is ISG15; the disease is abdominal aortic aneurysm.