Impediment in maternal RNA clearance by genetic inactivation of the RNA degradation-associated genes Btg4, Pabpn1l, or Cnot6l leads to MZT failure and female infertility in mice (Liu et al., 2016; Yu et al., 2016; Sha et al., 2018; Zhao et al., 2020). Here, PABPN1L is linked to female infertility.