Increased glycolysis in tumor tip ECs is regulated by the glycolytic activators 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and phosphofructokinase 1 (PFK1), which are important for cell migration and proliferation (De Bock et al., 2013b). The gene discussed is PFKM; the disease is neoplasm.