For instance, the authors discovered that Ginsenoside Rg3, an anti-cancer compound, can downregulate CCAT 1 thereby inactivating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway and eventually inhibiting proliferation, migration and invasion of CRC cells (46). The gene discussed is AKT1; the disease is colorectal carcinoma.