CDKN1A and colorectal carcinoma: Downregulation of CCAT 1 upregulates the expression of cyclin dependent kinase inhibitor 1A (CDKN1A) mRNA, which regulates G1 cell cycle arrest and leads to a reduction in colon cancer cell proliferation (14, 45)Moreover, by knocking down CCAT 1, the malignant characteristic of CRC cells, such as migration and invasion can be reversed (28).