The results showed that oxidative phosphorylation‐related genes such as ATP6, ND4 and COX1 and regeneration‐related genes such as CYTB decreased while mitophagy‐related genes BNIP3, IL17 signal pathway‐related genes TRAF6 were increasingly expressed in IDD (Figure 3M). The gene discussed is BNIP3; the disease is intervertebral disk degenerative disorder.