The Vit.D/VDR signaling pathway provides several promising influences in bacterial‐induced acute respiratory distress syndrome (ARDS) through different mechanisms, including regulation of the renin‐angiotensin pathways, restriction of cytokine storms specially IL‐6, a key interleukin in viral replication, protection of physical barrier in pulmonary epithelial, and stimulation of neutrophils (Xu et al., 2017; Zheng et al., 2020). The gene discussed is VIT; the disease is acute respiratory distress syndrome.