TP53 and cancer: Study examining the ovarian circRNA respectively from old group and young group by RNA sequencing found changed expression of 401 circRNAs, of which circDDX10 is suggested to form a pathway of circDDX10-miR-1301-3p/miR-4660-SIRT3 [232], with mitochondria-localized protein SIRT3 being a family of NAD+-dependent histone deacetylase and functioning in progress of aging and cancer by interacting closely with cellular tumor antigen p53 (P53) [233].