Furthermore, MenaINV expression in the tumor cells followed the same trend as the NF-κB signaling activation: paclitaxel, compared to control, increased MenaINV expression, whereas clodronate abrogated paclitaxel-mediated induction of MenaINV expression as well as lowered MenaINV expression below the baseline observed in chemotherapy naïve animals (Fig. 6D and Additional file 9: Fig. S8D). The gene discussed is NFKB1; the disease is neoplasm.