In detail, studies revealed that early AFB (younger than 20 years) was associated with several cardiovascular factors by mid-life, including body mass index, obesity, blood pressure, cholesterol, triglycerides, glycated haemoglobin, C reactive protein, von Willebrand factor, and fibrinogen [8–10, 12]. Here, VWF is linked to obesity due to melanocortin 4 receptor deficiency.