IRF4 and chronic myelogenous leukemia, BCR-ABL1 positive: For example, miR-877 inhibits progression of gastric cancer by down-regulating AQP3 [17], and miR-125b induces bone marrow and B-cell leukemia by inhibiting IRF4 [18], indicating that many up-regulated miRNAs in CML samples may inhibit the expression of target genes.