CD274 and inborn error of immunity: We further performed functional analysis of these shared DEGs, and the results of KEGG analysis showed that most of the down-regulated genes were mainly enriched in immune-related signaling pathways, such as Th1 and Th2 cell differentiation, primary immunodeficiency, T cell receptor signaling pathway, antigen processing and presentation, natural killer cell mediated cytotoxicity, PD-L1 expression and PD-1 checkpoint pathway in cancer, cytokine-cytokine receptor interaction, chemokine signaling pathway, B cell receptor signaling pathway (Fig. 1D).