PTEN and neoplasm: Moreover, miR-25 overexpression has been associated with tumor progression and poor prognosis in colorectal cancer (CRC) [53], while exosomal miR-25 has been documented to induce macrophage M2 polarization, via PTEN targeting and PI3K/ACT activation, promoting EMT, angiogenesis and tumor metastasis in CRC [54, 55].