In addition, miR-25-targeting of PTEN has been demonstrated in vitro to activate PI3K/AKT pathway, resulting in MM proliferation and apoptosis attenuation, while MYC-induced overexpression of miR-25 was documented to mediate dexamethasone resistance in MM via targeting ULK1 and p27 [48, 49]. This evidence concerns the gene AKT1 and Miyoshi myopathy.