Furthermore, Table 2 reveals that the intensity of infiltrating CD8+T cells in HCC tissues could be an independent prognostic factor for the survival prediction of HCC patients (uni-variate: HR = 0.451, 95% CI: 0.255–0.798, P = 0.006, multi-variate: HR = 0.470, 95% CI: 0.238–0.928, P = 0.030). This evidence concerns the gene CD8A and hepatocellular carcinoma.