Moreover, the tumor cell-derived CXCL6, CXCL2, and CCL20, TAM-derived CXCL9/CXCL10, and the stromal cell-derived CXCL12 also contributed to the accumulation of tissue-resident CD103+CD8+TILs in the TME. This evidence concerns the gene CXCL12 and neoplasm.