To study the regulation of CD8+CD103+TILs by other cells in the TME, scRNA-seq data of CD8+CD103+TILs in HCC and ICC were collected from GEO datasets (GSE: 125449) [7] according to the standard process of the Seurat package and UMAP analysis. Here, ITGAE is linked to intrahepatic cholangiocarcinoma.