Consistent with results of GSE68468 and GSE41258, the mRNA levels of CLU, SFTPD, CCL18, SPP1, APOE and BGN were found to be significantly increased (Fig 4A, B AND E-H), while MMP3 and CXCL5 were notably decreased in metastatic CRC compared with primary CRC (Fig. 4I, J). This evidence concerns the gene SPP1 and colorectal carcinoma.