The results of univariate logistic regression indicated that CYP2C19 *1/*2 (*1/*2 vs. *1/*1: odds ratio (OR) 1.537, 95% confidence interval (CI): 1.304–1.811, P < 0.001), *1/*3 (*1/*3 vs. *1/*1: OR 1.442, 95% CI: 1.049–1.983, P = 0.024), *2/*2 (*2/*2 vs. *1/*1: OR 2.441, 95% CI: 1.806–3.301, P < 0.001) genotypes may increase risk of hypertension. This evidence concerns the gene CYP2C19 and Hypertension.