CYP2C19 and hypertensive disorder: And the CYP2C19 IM genotypes (IM vs. EM: OR 1.514, 95% CI: 1.291–1.774, P < 0.001), PM genotypes (PM vs. EM: OR 2.119, 95% CI: 1.637–2.743, P < 0.001), IM + PM genotypes (IM + PM vs. EM: OR 1.617, 95% CI: 1.390–1.881, P < 0.001) may increase risk of hypertension (Table 5).