The proportion of CYP2C19 rs4244285 G/A genotype (46.0% vs. 39.6%, P < 0.001), A/A genotype (10.8% vs. 5.9%, P < 0.001), and A allele (33.8% vs. 25.7%, P < 0.001) in hypertension group was significantly higher than that in control group. This evidence concerns the gene CYP2C19 and Hypertension.