CYP2C19 and hypertensive disorder: And the CYP2C19 IM genotypes (IM vs. EM: OR 1.523, 95% CI: 1.300-1.785, P < 0.001), PM genotypes (PM vs. EM: OR 2.127, 95% CI: 1.645–2.749, P < 0.001) may increase risk of hypertension.