The results of multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated that CYP2C19 *1/*2 (*1/*2 vs. *1/*1: OR 1.529, 95% CI: 1.296–1.803, P < 0.001), *1/*3 (*1/*3 vs. *1/*1: OR 1.423, 95% CI: 1.034–1.960, P = 0.030), *2/*2 (*2/*2 vs. *1/*1: OR 2.433, 95% CI: 1.797–3.293, P < 0.001) genotypes may increase risk of hypertension. This evidence concerns the gene CYP2C19 and hypertensive disorder.