EMILIN1 and neoplasm: Elastin Microfibril Interface Located proteINs (EMILINs) [7] are a novel family of extracellular matrix glycoproteins, including elastin microfibril interface-located protein-1 (EMILIN-1), EMILIN-2, EMILIN-3, EMILIN-4, and EMILIN-5 [8], which are abundantly expressed in elastic-rich tissues such as heart, blood vessels and skin [9], and are closely associated with elastogenesis, development of the cardiovascular system and progression of related diseases, and tumor growth [10–13].