We found that the expression of TP53 is not an indicator of prognosis in total HNSCC and HPV(-) HNSCC patients (HR=0.97, p=0.632; HR=1.04, p=0.555), but is significant only in HPV(+) patients (HR=0.65, p=0.0157). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.