The top 10 mutated genes in PAAD patients were: TP53, KRAS, CDKN2A, SMAD4, TTN, LRP1B, RNF43, MUC16, PEG3, and MYO16. The most frequently mutated genes in both risk groups are presented in Fig. 7B. Mutations in USH2A were only found in the high-risk group. The gene discussed is RNF43; the disease is pancreatic adenocarcinoma.