In the TCGA database, there were 11 kinds of immune cells differentially infiltrating between pancreatic cancer and adjacent tissues according to the CIBERSORT algorithm (Fig. 1A).In GSE62452 dataset, a total of 5 immune cells(memory B cells, memory resting CD4 T cells, M0 macrophages, M2 macrophages, activated dentritic cells) were highly infiltrated in pancreatic cancer tissues, while 6 kinds of immune cells are highly infiltrated in normal tissues (naïve B cells, plasma cells, CD8 T cells, activated NK cells, monocytes, resting dentritic cells) (Fig. 1B). This evidence concerns the gene CD4 and pancreatic neoplasm.