In our current study, the expression of 12 immune checkpoint genes (CD40, TNFRSF4, CD86, LAIR1, TNFRSF14, HAVCR2, CD244, TMIGD2, TNFRSF9, KIR3DL1, TNFRSF8, and CD48) were downregulated in PAAD tissues compared with the normal group. This evidence concerns the gene HAVCR2 and pancreatic adenocarcinoma.