In all patients with AIDS combined with cryptococcosis, 45 patients (75.0%) had a cough as the main manifestation, 29 patients (48.3%) had a fatigue, 26 patients (43.3%) had a headache, 20 patients (33.3%) had nuchal rigidity, 16 patients (26.6%) had vomiting, 8 patients (13.3%) had baseline CD4 + T-lymphocyte count above 100 cells/μl. The gene discussed is CD4; the disease is cryptococcosis.