When comparing the first intracranial pressure elevation and the cerebrospinal fluid India ink staining, cerebrospinal fluid culture results, cerebrospinal fluid white blood cell count, cerebrospinal fluid protein level, baseline CD4 + cell count, CD4/CD8, age, days in the hospital, duration of HIV diagnosis and cerebrospinal fluid glucose level between the two groups, the AIDS combined with CM group had a high positive rate with statistical differences (P < 0.05). This evidence concerns the gene CD4 and AIDS.