Studies have shown that butyrate produced by Prevotellaceae can regulate pro-inflammatory cytokines IL-1β and TNF-α through NF-κB signaling [56], Prevotellaceae was also closely related to inflammation in mice with colitis [57], Ffar2 signaling in colon cancer regulates intestinal health by regulating the abundance of Prevotellaceae, and SCFA receptors Ffar2 and Hcar2 induce inflammatory body activation to balance colon Treg cell homeostasis [58]. Here, NFKB1 is linked to colonic neoplasm.