We observed statistically significant differences in pre-transplant PIVKA-II and AFP values between the group with a diameter of the largest tumour lesion at diagnosis ≤ 3 cm and the group with lesions > 3 cm, such that patients with a tumour size > 3 cm had significantly higher serum PIVKA-II and AFP levels than those with a tumour size < 3 cm. The gene discussed is AFP; the disease is neoplasm.