Deconvolution of the unfavorable wound healing (C1) predictors suggested that the EMT and TGF-β signatures predominantly reflected fibroblasts and endothelial cells as opposed to a mesenchymal epigenetic state per se within the tumor cells; conversely, some of the dominant single-gene transcriptional predictors such as AUTS2 and TCF7L1 demonstrated substantial tumor intrinsic expression (Fig. 7b and Extended Data Fig. 10b). The gene discussed is TCF7L1; the disease is neoplasm.