Analysis of these 17 DEPs using IPA revealed five canonical pathways (Table S4): ‘acute phase response signaling (APR),’ ‘growth hormone signgling,’ ‘iron homeostasis signaling pathway,’ peroxisome proliferator-activated receptors (PPAR)/retinoid X receptor (RXR) activation,’ and ‘hypoxia-inducible factor 1 (HIF-1) signaling.’ IPA also identified ‘inflammatory response,’ ‘cancer,’ ‘organismal injury and abnormalities,’ and ‘metabolic disease’ as the top diseases and disorders associated with the presence of MIAC and IAI complicated by PPROM. This evidence concerns the gene GH1 and Other metabolic disease.