GPX4 and chordoma: For example, some genes that are highly essential in but have lower selectivity scores for chordoma, such as those encoding CDK7, CDK9, and GPX4—proteins against which small-molecule inhibition was previously shown to have antiproliferative effects in chordoma models17 – may represent cancer targets with potential relevance to diverse cancer types including chordoma (Supplementary Fig. 15)49,50.