Consistent with these findings, IFN-alpha- and IFN-gamma-response genes are the most enriched among upregulated genes following sgRNA-mediated repression of ADAR in chordoma cells using both gene-set enrichment analysis (GSEA)41 (Supplementary Fig. 8a and Supplementary Data 4), as well as a network-based enrichment method (GeLiNEA)42 (Supplementary Fig. 8b, c). Here, ADAR is linked to chordoma.