PTPN11 and melanoma: For comparison, we also tested the BRAFV600E-mutant A2058 melanoma cell line and the MDA-MB-468 breast adenocarcinoma cell line, which are reported to be insensitive and sensitive to SHP2 inhibition, respectively47, and which accordingly exhibit differential dependence on PTPN11 gene suppression (Supplementary Fig. 10).