In addition to TBXT, this analysis identified a diverse spectrum of selectively essential genes in chordoma, including PTPN11, ADAR, PRKRA, LUC7L2, SRRM2, SLC2A1, SLC7A5, FANCM, AHR, ARNT, HEATR3, UBIAD1, IER3IP1, PRKAR1A, ZEB2, DSCC1, and OTUD5 (Fig. 1b, c and Supplementary Fig. 2). Here, PRKRA is linked to chordoma.