Genes were selected to represent both those functionally connected to other chordoma dependency genes (PTPN11, FANCM, ADAR, PRKRA, SOX9, SRRM2, SLC2A1, and SLC7A5), as well as those with putatively unique effects (LUC7L2 and CDK6). The gene discussed is PRKRA; the disease is chordoma.