Among the 15 transcription factors, we characterized that NFKB2 was the one most correlated to CD70 expression validated in two NPC RNA-seq cohorts and Visium spatial data, and had the highest binding score to the CD70 promoter region predicted by JASPER (Figs. 7d, e and Supplementary Data 2). The gene discussed is CD70; the disease is nasopharyngeal carcinoma.