Meanwhile, the fractions of tumor-infiltrating Tregs and CD8+ cytotoxic T cells were significantly decreased and increased upon receiving the combination therapy, respectively (Fig. 4q and Supplementary Fig. 5g), suggesting that combining anti-CD70 and anti-PD-1 treatments achieved a synergistic effect that stimulated T-cell immunity by overcoming Treg-mediated immunosuppression. This evidence concerns the gene CD8A and neoplasm.