However, several other vital lipid metabolism-associated genes, including SQLE, SCAP, HMGCR, ATF4, CCDC5B, LAGLS3, CTNB1, and EGR1, were not differentially expressed (Fig. 6i), indicating an alternative and CD70-independent lipid signaling in Tregs within a tumor-specific niche. This evidence concerns the gene HMGCR and neoplasm.