It’s well known that OTUB1 contains two domains: the N-terminal ubiquitin-association (UBA) domain and the C-terminal ovarian tumor (OTU) domain.7 Deletion of the UBA domain disrupted the interaction between FGFR2 and OTUB1 (Fig. 3f), indicating that the interaction between OTUB1 and FGFR2 was dependent on the UBA domain of OTUB1, which is absent in OTUB2. This evidence concerns the gene FGFR2 and ovarian neoplasm.