FGFR2, a receptor for the cytokine FGF10, is a key regulator of bone development and cancer.48 Deletion of Fgfr2 isoforms results in osteogenesis dysfunction, suggesting its crucial role in bones.3,49–51 In this study, we discovered that FGFR2 is a potential substrate of OTUB1. This evidence concerns the gene FGF10 and cancer.