We performed CRISPRa screen in HepG2 cells, a hepatoblastoma-derived cell line20 that is highly sensitive to OXA as compared to HCC cell lines Huh7 and PLC-8024 (IC50: HepG2 4.76 μM; Huh7: 7.89 μM; PLC-8024: 18.19 μM) (Supplementary Fig. 1c). Here, HSPG2 is linked to hepatocellular carcinoma.