Because HEG1, but not BTBD7, was reported to directly contribute to survival, metastasis, and chemoresistance in HCC through regulation of Wnt/beta-catenin signaling29,30, a major signaling pathway regulating liver homeostasis and tumorigenesis31,32, we decided to examine the role of HEG1 in PRMT3- mediated OXA resistance. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.