CCND1 and Familial prostate cancer: Through the research on RNA binding protein Sam68, Paronetto et al. found that Sam68 was recruited to CCND1 and interacted with the proximal region of intron 4 to regulate its affinity for CCND1 intron 4, thereby stimulating the increase of CCND1b transcript in human prostate cancer PC3 cell line in vitro [121].