RAD51 and malignant colon neoplasm: A study on colon cancer revealed that CCND1a increased the phosphorylation of γH2AX induced by chemotherapy agents (doxorubicin or 5-fluorouracil) and recruited Rad51 to local chromatin in response to DNA damage, triggering DDR characterized by phosphorylation of γH2AX in colon cancer HCT116 cell line in vitro.