The results showed that knockdown of STAT3 expression by siRNA decreased RKO cell proliferation (Fig. 5H–J), but increased the expression of chemokines (Fig. 5D, E) and proinflammatory factors (Fig. 5F, G) and completely reversed the CMTR1-mediated induction of tumor cell proliferation and immune responses. This evidence concerns the gene CMTR1 and neoplasm.