According to the gene expression profile and clinical data obtained from the TCGA-COAD dataset, the expression of CMTR1 was significantly higher in tumor tissues than in normal controls and increased with pathologic stage (Fig. 1C), and Kaplan‒Meier survival analysis indicated that high CMTR1 expression was correlated with poor prognosis (Fig. 1D). This evidence concerns the gene CMTR1 and neoplasm.