TIPE3 and head and neck squamous cell carcinoma: Through in vitro and in vivo approaches, we demonstrated that the downregulation of TIPE3 might be responsible for the reconstruction of mitochondria stress hemostasis and help cancer cells evading from cell death in HNSCC, which might uncover a novel molecular mechanism regulating mitochondrial stress hemostasis and provide a novel insight into clinical therapy strategy development for HNSCC patients.