Recent findings further highlighted a more critical role of P2X7 over P2X4 in ARPKD cysts progression (Arkhipov et al., 2019; Xu et al., 2022); the role of pannexin‐P2X interaction in ADPKD development remains to be studied. This evidence concerns the gene P2RX7 and autosomal recessive polycystic kidney disease.