SGLT-2 inhibitors (odds ratio 0.66, 95% confidence interval 0.60 to 0.73; high certainty) decrease admission to hospital for heart failure as, probably, do GLP-1 receptor agonists (0.91, 0.83 to 0.99; moderate certainty) and finerenone (0.78, 0.66 to 0.92; moderate certainty). This evidence concerns the gene GLP1R and heart failure.