OPA1 and neoplasm: Finally, “OPA1-low” samples displayed a higher immune cytolytic activity score (P = 4.39 × 10−6) and ICR score (P = 1.60 × 10−5), which reflect an anti-tumor cytotoxic immune response, than “OPA1-high” samples, and higher scores for signatures associated with response to immune checkpoint inhibitors (ICI): T cell–inflamed signature (TIS) (P = 2.86 × 10−6) and tertiary lymphoid structure score (P = 5.66 × 10−7).