The consequences of mtDNA release in tumor microenvironment vary depending on the nature of infiltrating immunocytes, associated with the neutrophil-mediated worsening of tumor progression (Singel et al, 2019) or, reciprocally, with the stimulation of the cross-priming potential of cDC1 cells for the development of anti-tumor cytotoxic CD8 cells (Xu et al, 2017). This evidence concerns the gene CD8A and neoplasm.