Plasma proteins showing higher levels in diabetic rats included Delta-like 1 (DLL1) and ectodysplasin A2 receptor (EDA2R) (Figure S1C), both of which were recently found in a human proteomics study analyzing four independent cohorts of individuals with type 1 and type 2 diabetes and early and late DKD to be associated with progression to kidney failure.27 This evidence concerns the gene EDA2R and type 2 diabetes mellitus.