To identify proteins interacting with TLR2 in response to P. gingivalis, THP1 macrophages were infected with bacteria at multiplicity of infection (MOI) 10 for 30 min and then protein interactions were stabilized using the membrane-permeable crosslinker dithiobis (succinimidyl propionate) (DSP) that contains a central thiol-cleavable bond. This evidence concerns the gene TLR2 and infection.