Similar results were observed in a leukemia monocytic cell line THP-1 (Fig 2I–2K) and an endothelial cell line EA.hy926 (Fig 2L–2N), while dual-mutations of Lys406 and Lys442 did not further inhibit vIRF1’s function in blocking IFN-β production (S2 Fig). Here, IFNB1 is linked to leukemia.