Even though we found no differences in secretoneurin concentrations between very preterm infants with an imaging-based diagnosis of brain injury and those without, secretoneurin concentrations to a certain extent predicted neurodevelopmental outcome: Firstly, secretoneurin serum concentrations determined in UCB positively correlated with and significantly predicted Bayley-III motor scale scores, with lower concentrations being associated with lower scores. Here, SCG2 is linked to brain injury.