CKB and obesity due to melanocortin 4 receptor deficiency: In individuals with overweight and obesity, blood pressure and glucose caused 49.4% (95% CI = 40.1, 62.5) and 16.9% (95% CI = 13.6, 22.9) of the total effect of BMI on all-cause mortality in CKB and 9.1% (95% CI = 2.2, 25.9) and 16.7% (95% CI = 7.3, 49.0) in NHANES (Table 1 and Table 2).