For associations between BMI and mortality in subjects with overweight or obesity, the mediator proportion of blood pressure and glucose was 49.4% (95% CI = 40.1, 62.5) and 16.9% (95% CI = 13.6, 22.9) in CKB and 9.10% (95% CI = 2.2, 25.9) and 16.7% (95% CI = 7.3, 49.0) in NHANES, respectively. Here, CKB is linked to obesity due to melanocortin 4 receptor deficiency.