Similarly, here, the increase in C1q and C3 combined with C2 and C4a following ZIKV infection may result in increased C1q cleavage and formation of excessive C3b and hence have a greater impact on neuronal development than DENV, which does not induce C2 and C4a and thus may maintain more C1q and less C3b. This evidence concerns the gene C4A and Zika virus infectious disease.