Ddit3 has been shown in the adult to contribute to retinal ganglion cell death (Wang et al. 2021) and consistent with the increase in Ddit3 seen here, and the pathology seen at later stages of ZIKV-infection in a similar model is loss of the RGC layer of the retina (Li et al. 2021; Shi et al. 2018). This evidence concerns the gene DDIT3 and Zika virus infectious disease.